❚ Gamma Frequency Entrainment Attenuates Amyloid Load and Modifies Microglia
Iaccarino H. F. et al. (2016)
❚ Noninvasive 40-Hz Light Flicker to Recruit Microglia and Reduce Amyloid Beta Load
Singer A. C. et al. (2018)
❚ Gamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer’s Disease
McDermott B. et al. (2018)
❚ Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition
Martorell, A. J. et al. (2019)
❚ Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities
Adaikkan C. & Tsai L-H. (2019)
❚ Optimal Flickering Light Stimulation for Entraining Gamma Waves in the Human Brain
Lee K., Park Y., Suh S.W. et al. (2021)
Source: New Insights Into the Pathogenesis of Alzheimer’s Disease – Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/A-series-of-studies-from-Li-Huei-Tsai-indicating-that-gamma-stimulations-ameliorate_fig2_338505918 [accessed 12 Oct, 2021]
GAMMA BRAIN WAVES
The neuronal changes resulting from Alzheimer’s Disease are associated with the disruption of neural gamma oscillations (20-50 Hz) required for typical cognitive functioning.
LIGHT FLICKER STIMULATION
Recent studies found that exposure to 40 Hz flickering light corrects aberrant gamma oscillations and reduces Aβ and Tau protein accumulation in multiple Alzheimer’s disease mice models.
NEUROPROTECTION & IMPROVED COGNITION
Additionally, the exposure to 40 Hz flickering light therapy, for one hour a day, resulted in neuroprotective effects, and improved cognition and memory in mice models.
Mice exposed to 40 Hz light for 1 hour a day had increased expression of cytokines (proteins important for cell signaling) and indirectly impacted the activity of neuronal microglial cells (immune defence cells).
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