A New Hope for Alzheimer's Disease Patients

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Promising Alzheimer’s Breakthrough

In 2016, researchers at the Massachusetts Institute of Technology (MIT) discovered that exposing Alzheimer’s mouse models to LED lights flickering at 40 Hz every day for a week:

  • Stimulates γ Brain Waves

    It induces and stimulates gamma brain waves  in the visual cortex and hippocampus

  • Activates Microglia

    It increases activity of microglia (immune defense) and reduces the Amyloid Beta & Tau plaques across the cortex

  • Forbedrer Hukommelsen

    It leads to actual improvement of cognitive performance

Our Research

Marcus S. Carstensen, et al. "40 Hz invisible spectral flicker and its potential use in Alzheimer's light therapy treatment," Proc. SPIE 11221, Mechanisms of Photobiomodulation Therapy XV, 112210L (11 March 2020)

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Zibrandtsen IC, Agger M, Kjaer TW. "Gamma Entrainment in a Large Retrospective Cohort: Implications for Photic Stimulation Therapy for Alzheimer's Disease". J Alzheimers Dis. 2020;75(4):1181-1190.

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Our Technology

Optoceutics develops a Masked 40 Hz light that removes flickering from normal stroboscopic 40 Hz light, while it retains the stimulation effect on the brain.

Take a closer look at the two types of flashing light in this short, informative video by our photonics researcher, Martin Thorning-Schmidt.

Research Background

Get Some Answers

What is the science behind it?

The study of 40 Hz light therapy and Alzheimer’s Disease appeared in the journal Nature in 2016 entitled Gamma frequency entrainment attenuates amyloid loading and alters microglia.

Be aware that although the experiments showed positive results on amyloid beta and cognitive ability, it is still only detected in mice.

What is Amyloid Beta?

Amyloid beta (sometimes called beta-amyloid or β-amyloid or Aβ) is a neural peptide or amino acid that has been shown to aggregate or “clump” in Alzheimer’s Disease.

While it is not clear whether amyloid beta is the cause of the disease, a mechanism to combat it, or simply a result of it, there is a strong correlation between the severity of the disease and the amount of amyloid beta in the brain.

For this reason, a huge amount of resources have been spent on developing therapies designed to reduce the accumulation of amyloid beta in the brain. Some of these treatments are currently undergoing clinical trials, including gamma therapy.

What is Gamma Stimulation?

The gamma brain frequency is often used in neuroscience and physiology to represent phenomena that occur approximately 40 times per second, or 40 Hertz (Hz).

It is not known why the gamma frequency activates cellular processes, but probably represents a complex phenomenon with both large-scale neuronal networks and subcellular interactions.

Importantly, in the mice study, frequencies outside the gamma range of 40 Hz have been shown not to have the same effect with regard to the clearance of amyloid beta.

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